Professor Thorsten Wahlers

Organisation / Institute
Department of Cardiac and Thoracic Surgery
Cologne University Heart Center

Address

Prof. Thorsten Wahlers
Department of Cardiac and Thoracic Surgery
Cologne University Heart Center
Kerpener Str. 62
50937 Köln, Germany

thorsten.wahlers[at]uk-koeln.de

 

 

 

 

PD Dr. Yeong-Hoon Choi

Organisation / Institute
Department of Cardiac and Thoracic Surgery
Cologne University Heart Center

Address

PD Dr. Yeong-Hoon Choi
Department of Cardiac and Thoracic Surgery
Cologne University Heart Center
Kerpener Str. 62
50937 Köln, Germany

yh.choi[at]uk-koln.de

Prof. Thorsten Wahlers / PD Dr. Yeong-Hoon Choi

Project description:

The heterodimeric hypoxia inducible transcription factors (HIF) are the key regulators of the pro-angiogeneic response to hypoxia. However, not only hypoxia, also pro-inflammatory signaling (i.e. tumor necrosis factor-α (TNF-α) and nuclear factor-ĸB (NF-ĸB) activation) can directly induce the pro-angiogeneic HIF signaling pathway.

Pressure overload left ventricular hypertrophy (LVH) results - if untreated – in progressive heat failure. While hypoxia as well as inflammation markers are elevated in LVH, the hypertrophic myocardium fails to respond to the pro-angiogeneic signaling, resulting in progressive heart failure. The aim of the presented proposal is investigate whether the increased expression of TNF-α in LV hypertrophy results in differential expression of the hypoxia inducible factors-1 and -2 and, thereby, preventing the adaptive angiogenesis. If this is the case, strategies will be developed to disrupt this cascade by manipulating the inflammatory environment, in order to preserve the relationship between contractile mass and blood supply, possibly delaying the onset of LV dilation and heart failure.

 

PD Dr. Yeong-Hoon Choi Profile:

Yeong-Hoon Choi is Assistant Professor of Cardiothoracic Surgery and appointed as a senior staff surgeon at the Dept. of Cardiac and Thoracic Surgery at the University Heart Center of Cologne. He received his medical doctor at the University of Mainz, Germany, and his clinical training and research expertise at the Universities of Mainz, Rostock, Cologne and at Harvard Medical School in Boston (MA). Currently, he is the Head of the Cardiac Surgical Research Laboratory and supervising he own research group.

Dr. Choi’s work has also been acknowledged by several prestigious awards, including the Wilhelm P Winterstein Award by the German Heart Foundation and the Ernst Derra Award by the German Society of Thoracic, Cardiac and Vascular Surgery.

 

Research interests:

The main focus of the laboratory are: patho-mechanisms of the development of myocardial hypertrophy and cell based regenerative therapy approaches involving pluripotent cell derived cardiac cells and adult stem cells using in vitro, small animal and large animal models. Besides cell and molecular biological methods, the laboratory has an emphasize on non-invasive imaging methods for in vivo cell tracking and the assessment of heart function parameters using magnetic resonance imaging (MRI). With our research we hope to elucidate potential pathways and mechanisms which could lead to the development of innovative regenerative treatments heart disease.